Alloantibody Exchange

Saving lives by helping blood bank software vendors work together

Announcement
Would you like to support the Alloantibody Exchange? For a variety of options, email us at

TRANSFUSION SAFETY

Blood bank software vendor Committed to share
patient's alloantibody history

Encourage your vendor to join the Alloantibody Exchange.

OUR MISSION

The Alloantibody Exchange is a cloud-based API that interfaces with software used by blood banks. This interface facilitates the exchange of patient's alloantibody histories between blood banks. Details »

SUPPORTERS

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SUPPORTED BY RESEARCHERS

Positive impact of online inter-hospital consultation of transfusion history on incidence of red cell ABO mistransfusions, acute and delayed hemolytic transfusion reactions

"Rate of ABO incompatibility decreased 4.6-fold, that of AHTR decreased 2-fold and that of DHTR decreased 2.5-fold pre vs post consultation of OLPTH (OnLine the Past Transfusion History, a Quebec-based transfusion history exchange)."
Pierre Robillard, et al.

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Enhanced detection of blood bank sample collection errors with a centralized patient database

"Access to a centralized patient database detected 38 percent more ABO typing errors and prevented six mistransfusions, which would not have been prevented at a single institution. Centralization of patient transfusion data should be encouraged."
Duncan MacIvor, et al.

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Regional registry of patient alloantibodies: first-year experience

"The regional alloantibody registry prevented potential delayed hemolytic transfusion reactions"
Vicki Schwickerath, et al.

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The Canadian transfusion surveillance system: what is it and how can the data be used?

"Since the implementation of this system there has been a significant drop in the frequency of ABO incompatible transfusions, acute hemolytic transfusion reactions and delayed transfusion reactions; hence, safety of the blood system in Québec has been enhanced."
Julie Ditomasso, et al.

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The immunohematologic and patient safety benefits of a centralized transfusion database

"The database provides evidence that sharing transfusion information, within regulatory requirements, tangibly improves patient care."
Meghan Delaney, et al.

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A centralized recipient database enhances the serologic safety of RBC transfusions for patients with sickle cell disease

“A centralized database can help prevent issuing incompatible RBC units”
Sarah K. Harm, et al.

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Record fragmentation due to transfusion at multiple health care facilities: a risk factor for delayed hemolytic transfusion reactions

"Almost two-thirds of records for patients tested at both hospitals had some form of discrepancy, most commonly the failure of one of the facilities to detect an antibody. Such discrepancies are serious since they constitute risk factors for incompatible transfusions and DHTRs (delayed hemolytic transfusion reactions)."
Nisha Unni, et al.

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High Percentage of Evanescent Red Cell Antibodies in Patients with Sickle Cell Disease Highlights Need for a National Antibody Database

“A national or regional alloantibody database should be a priority.”
Lance Williams, et al.

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A national Transfusion Register of Irregular Antibodies and Cross (X)-match Problems: TRIX, a 10-year analysis

"Databases for sharing transfusion information between hospitals for enhanced detection of blood type errors and prevention of adverse events are scarce but have a proven positive effect on the prevention of acute and delayed hemolytic transfusions."
Adriaan J. van Gammeren, et al.

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TRIX with treats: the considerable safety benefits of a transfusion medicine registry

"A national transfusion medicine registry could prevent DHTRs by sharing alloantibody records between blood banks."
Ronald 'George' Hauser, et al.

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Would a National Antibody Register contribute to improving patient outcomes?

"When taken together, the included studies have highlighted and investigated flaws in transfusion services provided around the world, many of which have the potential to be significantly reduced through the introduction of a National registry."
Zachary Powell, et al.

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A case for a national registry of red blood cell antibodies

"This case is an example of how a registry of RBC antibodies is critical to providing good patient care."
Gagan Mathur, et al.

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IN THE NEWS

SCC Soft Computer is proud to announce the development of the SoftBank® interface to the Alloantibody Exchange

"In collaboration with industry experts, SCC Soft Computer is developing an interface directly to the National Antibody Registry, with the goal to increase transfusion safety by improving shared patient antibody information between various facilities. "

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AABB Weekly Report - Top Story

"Jeanne Hendrickson, MD, professor of laboratory medicine at Yale University, is working with many others on developing a proposal for the creation of a nationwide registry to track patients’ antibodies."

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United Kingdom's National Health Service Adopts a National Patient Irregular Antibody Database

"Results are entered on the NHSBT national patient database and an antibody card will be issued for patients with irregular antibodies."

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ASCP, Blood Bank Community Working to Develop Nationwide Patient RBC Alloantibody Database/Registry

"Most recently, the American Society of Clinical Pathology has convened an inclusive group of stakeholders to address development of a nationwide patient RBC alloantibody database/registry."

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U.S. Department of Health and Human Services, Report to Congress

"There is no national alloantibody registry, which means one hospital is not aware of antibodies detected at other hospitals. This presents a problem for patients receiving care at more than one hospital since the evanescent nature of these antibodies places patients at risk for adverse transfusion events, which can be fatal." (page 66)

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AABB: Nationwide Antibody Registry Could Help Further Reduce Risk of Adverse Events Among Patients Receiving Blood Transfusions

"Such a registry will be particularly important for alloimmunized patients who have been cared for at more than one hospital system. If this project is successfully implemented, it will further advance our goal of optimizing transfusion medicine quality and safety for all patients."

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Letter to Sunquest from Henry Ford Health System

"We urge you (Sunquest) to consider updating your software such that participation in an antibody registry is possible."

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Alloantibody Exchange White Paper

"The high RBC alloimmunization rate, the high antibody evanescence rate, and the need to seek medical care at multiple hospitals over a lifetime, put individuals living with sickle cell disease at the highest risk for hemolytic transfusion reactions and death from transfusions."

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Letter to Sunquest from University of Washington

"As your client, we are writing this letter to express our interest in having Sunquest participate in the proposed US-wide red blood cell antibody exchange as a patient safety initiative."

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Letter to Sunquest from Maine General Medical Center

"We urge you to consider updating your software such that paticipation in such an antibody exchange is possible."

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Microsoft provides grant for cloud services through Azure.

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Letter to Cerner from Children's National

"Along with many other research and academics, we would like to emphasize the importance of being able to exchange red blood cell alloantibody information between hospitals."

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Letter to Wellsky from University of Florida

"As your client, we request your participation in a red blood cell alloantibody registry, developed by Transfusion Antibody Exchange, Inc., to exchange transfusion antibody data between hospital systems."

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Clinician researcher Sean Stowell (Emory University) describes how patient movement between healthcare facilities leads to delayed hemolytic transfusion reactions (DHTRs), hyperhemolysis, and patient death.

The video lecture describes this from 41:00 to 43:00.

Listen here »

Letter to Wellsky from Samaritan Hospital

"We believe in the importance of being able to exchange red blood cell alloantibody information between hospitals."

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Letter to Haemonetics, Soft, Sunquest, & Wellsky from University of California Health - UC Davis, UC San Diego, UC Irvine, UC Los Angeles (UCLA), UC San Francisco (UCSF)

"As innovators in healthcare, we at the University of California (UC) Health pride ourselves in adopting available technologies to keep up with, and set, trends; the exchange of red blood cell (RBC) alloantibody information between hospitals is one such innovation."

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Letter to Wellsky from University of Florida - Jacksonville

"I believe that access to antibody data from hospitals outside of our system will improve transfusion safety through shared knowledge of evanescent antibodies which are otherwise undetectable and may cause delayed hemolytic transfusion reactions."

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Letter to Cerner from University of Alabama - Birmingham

"There is an urgent and unmet neet to exchange transfusion and antibody data between hospital systems in our country."

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Letter to Haemonetics, SCC Soft Computer, Sunquest, and Wellsky from University of Pittsburgh

"The southwestern Pennsylvania region has had a centralized database of patient red cell antibody status for the last 25 years. As Medical Director of the regional transfusion service covering 22 hospitals, I can attest to the added safety. In fact, we have published a manuscript showing that acute hemolytic transfusion reactions from ABO errors have been prevented using this database."

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Jeanne Hendrickson discusses the Alloantibody Exchange at the Margot S. Kruskall Lectureship

"Delayed Hemolytic Transfusion Reactions: Diagnosis, Treatment, and Future Directions"

Lecture Schedule »

Letter to Cerner from MedStar Health

"We are writing this letter as your client to urge you to consider updating your software to allow participation in the Alloantibody Exchange. We consider this functionality to be of the utmost importance and anticipate it will be a major differentiation in our future choice of BBIS."

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ABOUT US

  We're a 501c3 nonprofit organization with a mission to make blood transfusion safer by enabling blood banks to share a patient's alloantibody history via their blood bank software vendor. Contact us at
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Ronald 'George' Hauser, MD

President, Founder. Yale University School of Medicine.

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Jeanne Hendrickson, MD

Board member, Founder. Yale University School of Medicine.

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Khalda A. Ibrahim, MD

Board member. University of California, Los Angeles.

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Greg Olsen, MD, MBA

Board member. University of Florida.

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Christopher Tormey, MD

Board member, Founder. Yale University School of Medicine.

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Ugo Ugwuowo, MD

VP Special Projects. Yale University School of Medicine.