Alloantibody Exchange
Sharing patient's transfusion histories makes blood transfusion safer
Sharing patient's transfusion histories makes blood transfusion safer
| Blood bank software vendor |
Committed to share patient's alloantibody history |
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"Rate of ABO incompatibility decreased 4.6-fold, that of AHTR decreased 2-fold and that of DHTR decreased 2.5-fold pre vs post consultation of OLPTH (OnLine the Past Transfusion History, a Quebec-based transfusion history exchange)."
Pierre Robillard, et al.
"Access to a centralized patient database detected 38 percent more ABO typing errors and prevented six mistransfusions, which would not have been prevented at a single institution. Centralization of patient transfusion data should be encouraged."
Duncan MacIvor, et al.
"The regional alloantibody registry prevented potential delayed hemolytic transfusion reactions"
Vicki Schwickerath, et al.
"Since the implementation of this system there has been a significant drop in the frequency of ABO incompatible transfusions, acute hemolytic transfusion reactions and delayed transfusion reactions; hence, safety of the blood system in Québec has been enhanced."
Julie Ditomasso, et al.
"The database provides evidence that sharing transfusion information, within regulatory requirements, tangibly improves patient care."
Meghan Delaney, et al.
“A centralized database can help prevent issuing incompatible RBC units”
Sarah K. Harm, et al.
"Almost two-thirds of records for patients tested at both hospitals had some form of discrepancy, most commonly the failure of one of the facilities to detect an antibody. Such discrepancies are serious since they constitute risk factors for incompatible transfusions and DHTRs (delayed hemolytic transfusion reactions)."
Nisha Unni, et al.
“A national or regional alloantibody database should be a priority.”
Lance Williams, et al.
"Databases for sharing transfusion information between hospitals for enhanced detection of blood type errors and prevention of adverse events are scarce but have a proven positive effect on the prevention of acute and delayed hemolytic transfusions."
Adriaan J. van Gammeren, et al.
"A national transfusion medicine registry could prevent DHTRs by sharing alloantibody records between blood banks."
Ronald 'George' Hauser, et al.
"When taken together, the included studies have highlighted and investigated flaws in transfusion services provided around the world, many of which have the potential to be significantly reduced through the introduction of a National registry."
Zachary Powell, et al.
"This case is an example of how a registry of RBC antibodies is critical to providing good patient care."
Gagan Mathur, et al.
"We call upon policymakers to consider creating a nationwide database of all SCD patients, regardless of where they have received care. This database should include information on patient blood group genotypes, phenotypes, antibodies, and transfusion histories"
Mischa Covington, et al.
"In collaboration with industry experts, SCC Soft Computer is developing an interface directly to the National Antibody Registry, with the goal to increase transfusion safety by improving shared patient antibody information between various facilities. "
"Jeanne Hendrickson, MD, professor of laboratory medicine at Yale University, is working with many others on developing a proposal for the creation of a nationwide registry to track patients’ antibodies."
"Results are entered on the NHSBT national patient database and an antibody card will be issued for patients with irregular antibodies."
"Most recently, the American Society of Clinical Pathology has convened an inclusive group of stakeholders to address development of a nationwide patient RBC alloantibody database/registry."
"There is no national alloantibody registry, which means one hospital is not aware of antibodies detected at other hospitals. This presents a problem for patients receiving care at
more than one hospital since the evanescent nature of these antibodies places patients at risk for adverse transfusion events, which can be fatal." (page 66)
"Such a registry will be particularly important for alloimmunized patients who have been cared for at more than one hospital system. If this project is successfully implemented, it will further advance our goal of optimizing transfusion medicine quality and safety for all patients."
"We urge you (Sunquest) to consider updating your software such that participation in an antibody registry is possible."
"The high RBC alloimmunization rate, the high antibody evanescence rate, and the need to seek medical care at multiple hospitals over a lifetime, put individuals living with sickle cell disease at the highest risk for hemolytic transfusion reactions and death from transfusions."
"As your client, we are writing this letter to express our interest in having Sunquest participate in the proposed US-wide red blood cell antibody exchange as a patient safety initiative."
"We urge you to consider updating your software such that paticipation in such an antibody exchange is possible."
"Along with many other research and academics, we would like to emphasize the importance of being able to exchange red blood cell alloantibody information between hospitals."
"As your client, we request your participation in a red blood cell alloantibody registry, developed by Transfusion Antibody Exchange, Inc., to exchange transfusion antibody data between hospital systems."
The video lecture describes this from 41:00 to 43:00.
"We believe in the importance of being able to exchange red blood cell alloantibody information between hospitals."
"As innovators in healthcare, we at the University of California (UC) Health pride ourselves in adopting available technologies to keep up with, and set, trends; the exchange of red blood cell (RBC) alloantibody information between hospitals is one such innovation."
"I believe that access to antibody data from hospitals outside of our system will improve transfusion safety through shared knowledge of evanescent antibodies which are otherwise undetectable and may cause delayed hemolytic transfusion reactions."
"There is an urgent and unmet neet to exchange transfusion and antibody data between hospital systems in our country."
"The southwestern Pennsylvania region has had a centralized database of patient red cell antibody status for the last 25 years. As Medical Director of the regional transfusion service covering 22 hospitals, I can attest to the added safety. In fact, we have published a manuscript showing that acute hemolytic transfusion reactions from ABO errors have been prevented using this database."
"Delayed Hemolytic Transfusion Reactions: Diagnosis, Treatment, and Future Directions"
"We are writing this letter as your client to urge you to consider updating your software to allow participation in the Alloantibody Exchange. We consider this functionality to be of the utmost importance and anticipate it will be a major differentiation in our future choice of BBIS."
"As a practicing transfusion medicine specialist at a major academic medical center for the past 25 years, I understand well our collective need to be able to exchange red blood cell alloantibody information between hospitals."
"We use the Sunquest blood bank information system at UVA. As medical director of the UVA blood bank, I am writing this letter to express our strong interest in having you participate in the proposed US-wide red blood cell antibody exchange, the Alloantibody Exchange, as a patient safety initiative."
"I strongly urge you to consider updating your software such that participation in such an antibody exchange is possible."
"Over the years it has become clear that the capability to share red blood cell alloantibody information amongst hospital transfusion services has important patient safety benefits."
"We believe in the importance of being able to exchange red blood cell antibody information between hospitals."
"At Grady, we strive to provide the best care possible for our patients. ... This is why we are requesting your participating in a red blood cell alloantibody registry, developed by Transfusion Antibody Exchange, Inc, to exchange transfusion antibody data between hospital systems."
"At Stanford Medicine, we are strongly committed to innovation and continued improvement in patient safety. We believe that the safety of transfusion medicine will improve from the exchange of red blood cell alloantibody information between hospitals across the nation."
"As your client, we are writing this letter to express our interest in having Haemonetics participate in the proposed US-wide red blood cell antibody exchange, the Alloantibody Exchange, as a patient safety initiative. We urge you to consider updating your software such that participation in such an antibody exchange is possible."
"We serve as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho and receive patients from across the country as they seek out routine care as well as innovative treatments such as stem cell transplant, immunotherapy, and gene therapy. Exchange of red blood cell alloantibody information between hospitals is an important advancement and innovation in transfusion medicine safety."
"Your willingness to participate in the Alloantibody Exchange to enable the exchange red blood cell alloantibody information between hospitals is appreciated and truly improves patient care."
"As a representative of Boston Children’s Hospital, the #1 U.S. News & World Report Children’s Hospital for 9 years in a row, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."
"As transfusion medicine physicians delivering care within such a healthcare environment, we daily experience the very real need of being able to share RBC alloantibody information between your two different transfusion laboratory information systems within our own healthcare organization as well as between transfusion laboratory information systems with other healthcare organizations across our nation."
"As leaders in healthcare, we as members of the Massachusetts General Brigham (Massachusetts General
Hospital, Brigham and Women’s Hospital and affiliated hospitals) system seek to adopt new technology to
improve the safety and operational efficiency of our blood banks. The exchange of red blood cell (RBC)
alloantibody information between hospitals through vendor collaboration, as proposed by the Alloantibody
Exchange, is one such innovation."
"As a representative of Cincinnati Children’s Hospital, a top children's hospital according to U.S. News & World Report, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."
"As a blood bank information system client, we are writing this letter to express our interest in having you participate in the proposed US-wide red blood cell antibody exchange as a patient safety initiative."
"This novel project will improve transfusion safety by sharing the incidence of possibly undetectable evanescent antibodies."
"Patients who are chronically transfused and allo-immunized will benefit from receiving phenotypically matched blood but may not receive that standard of care depending on the hospital they receive transfusion at; as a result they may become further alloimmunized unnecessarily."
"As medical directors for your client, we are writing this letter to express our interest in having your participate in the proposed US-wide red blood cell antibody exchange."
"As a representative of Atrium Health Wake Forest Baptist, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."
The Office of the Assistant Secretary for Health (OASH), within the U.S. Department of Health and Human Services (HHS), submission for a red blood cell antibody repository has been chosen for development as part of the HHS Secretary’s “Challenge on Equity.” The project is expected to be implemented in the next two years and is one of 24 innovative projects selected to advance equity in programs, policies, and processes across the agency. (page 5)
President, Founder.
Yale University School of Medicine.
Board member, Founder.
Emory University School of Medicine.
Board member.
University of California, Los Angeles.
Director of Communications.
University of New Haven.
Board member.
University of Florida.
Board member, Founder.
Yale University School of Medicine.
Director of Special Projects.
Yale University School of Medicine.
Director of Software.
Yale University School of Medicine.