Alloantibody Exchange

Sharing patient's transfusion histories makes blood transfusion safer

TRANSFUSION SAFETY

Supporters of an electronic system to share patient transfusion histories, including alloantibodies, antigens, and special transfusion requirements.

How would you like to use the Alloantibody Exchange?


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VENDOR SUPPORT FOR TRANSFUSION SAFETY

Blood bank software vendor Committed to share
patient's alloantibody history

Encourage your vendor to join the Alloantibody Exchange.

OUR MISSION

The Alloantibody Exchange is a cloud-based API that interfaces with software used by blood banks. This interface facilitates the exchange of patient's alloantibody histories between blood banks. Details »

SUPPORTERS

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SUPPORTED BY RESEARCHERS

Positive impact of online inter-hospital consultation of transfusion history on incidence of red cell ABO mistransfusions, acute and delayed hemolytic transfusion reactions

"Rate of ABO incompatibility decreased 4.6-fold, that of AHTR decreased 2-fold and that of DHTR decreased 2.5-fold pre vs post consultation of OLPTH (OnLine the Past Transfusion History, a Quebec-based transfusion history exchange)."
Pierre Robillard, et al.

View details »

Enhanced detection of blood bank sample collection errors with a centralized patient database

"Access to a centralized patient database detected 38 percent more ABO typing errors and prevented six mistransfusions, which would not have been prevented at a single institution. Centralization of patient transfusion data should be encouraged."
Duncan MacIvor, et al.

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Regional registry of patient alloantibodies: first-year experience

"The regional alloantibody registry prevented potential delayed hemolytic transfusion reactions"
Vicki Schwickerath, et al.

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The Canadian transfusion surveillance system: what is it and how can the data be used?

"Since the implementation of this system there has been a significant drop in the frequency of ABO incompatible transfusions, acute hemolytic transfusion reactions and delayed transfusion reactions; hence, safety of the blood system in Québec has been enhanced."
Julie Ditomasso, et al.

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The immunohematologic and patient safety benefits of a centralized transfusion database

"The database provides evidence that sharing transfusion information, within regulatory requirements, tangibly improves patient care."
Meghan Delaney, et al.

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A centralized recipient database enhances the serologic safety of RBC transfusions for patients with sickle cell disease

“A centralized database can help prevent issuing incompatible RBC units”
Sarah K. Harm, et al.

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Record fragmentation due to transfusion at multiple health care facilities: a risk factor for delayed hemolytic transfusion reactions

"Almost two-thirds of records for patients tested at both hospitals had some form of discrepancy, most commonly the failure of one of the facilities to detect an antibody. Such discrepancies are serious since they constitute risk factors for incompatible transfusions and DHTRs (delayed hemolytic transfusion reactions)."
Nisha Unni, et al.

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High Percentage of Evanescent Red Cell Antibodies in Patients with Sickle Cell Disease Highlights Need for a National Antibody Database

“A national or regional alloantibody database should be a priority.”
Lance Williams, et al.

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A national Transfusion Register of Irregular Antibodies and Cross (X)-match Problems: TRIX, a 10-year analysis

"Databases for sharing transfusion information between hospitals for enhanced detection of blood type errors and prevention of adverse events are scarce but have a proven positive effect on the prevention of acute and delayed hemolytic transfusions."
Adriaan J. van Gammeren, et al.

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TRIX with treats: the considerable safety benefits of a transfusion medicine registry

"A national transfusion medicine registry could prevent DHTRs by sharing alloantibody records between blood banks."
Ronald 'George' Hauser, et al.

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Would a National Antibody Register contribute to improving patient outcomes?

"When taken together, the included studies have highlighted and investigated flaws in transfusion services provided around the world, many of which have the potential to be significantly reduced through the introduction of a National registry."
Zachary Powell, et al.

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A case for a national registry of red blood cell antibodies

"This case is an example of how a registry of RBC antibodies is critical to providing good patient care."
Gagan Mathur, et al.

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Unmasking delayed hemolytic transfusion reactions in patients with sickle-cell disease: Challenges and opportunities for improvement

"We call upon policymakers to consider creating a nationwide database of all SCD patients, regardless of where they have received care. This database should include information on patient blood group genotypes, phenotypes, antibodies, and transfusion histories"
Mischa Covington, et al.

View details »

IN THE NEWS

SCC Soft Computer is proud to announce the development of the SoftBank® interface to the Alloantibody Exchange

"In collaboration with industry experts, SCC Soft Computer is developing an interface directly to the National Antibody Registry, with the goal to increase transfusion safety by improving shared patient antibody information between various facilities. "

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AABB Weekly Report - Top Story

"Jeanne Hendrickson, MD, professor of laboratory medicine at Yale University, is working with many others on developing a proposal for the creation of a nationwide registry to track patients’ antibodies."

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United Kingdom's National Health Service Adopts a National Patient Irregular Antibody Database

"Results are entered on the NHSBT national patient database and an antibody card will be issued for patients with irregular antibodies."

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ASCP, Blood Bank Community Working to Develop Nationwide Patient RBC Alloantibody Database/Registry

"Most recently, the American Society of Clinical Pathology has convened an inclusive group of stakeholders to address development of a nationwide patient RBC alloantibody database/registry."

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U.S. Department of Health and Human Services, Report to Congress

"There is no national alloantibody registry, which means one hospital is not aware of antibodies detected at other hospitals. This presents a problem for patients receiving care at more than one hospital since the evanescent nature of these antibodies places patients at risk for adverse transfusion events, which can be fatal." (page 66)

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AABB: Nationwide Antibody Registry Could Help Further Reduce Risk of Adverse Events Among Patients Receiving Blood Transfusions

"Such a registry will be particularly important for alloimmunized patients who have been cared for at more than one hospital system. If this project is successfully implemented, it will further advance our goal of optimizing transfusion medicine quality and safety for all patients."

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Letter to Sunquest from Henry Ford Health System

"We urge you (Sunquest) to consider updating your software such that participation in an antibody registry is possible."

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Alloantibody Exchange White Paper

"The high RBC alloimmunization rate, the high antibody evanescence rate, and the need to seek medical care at multiple hospitals over a lifetime, put individuals living with sickle cell disease at the highest risk for hemolytic transfusion reactions and death from transfusions."

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Letter to Sunquest from University of Washington

"As your client, we are writing this letter to express our interest in having Sunquest participate in the proposed US-wide red blood cell antibody exchange as a patient safety initiative."

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Letter to Sunquest from Maine General Medical Center

"We urge you to consider updating your software such that paticipation in such an antibody exchange is possible."

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Microsoft provides grant for cloud services through Azure.

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Letter to Cerner from Children's National

"Along with many other research and academics, we would like to emphasize the importance of being able to exchange red blood cell alloantibody information between hospitals."

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Letter to Wellsky from University of Florida

"As your client, we request your participation in a red blood cell alloantibody registry, developed by Transfusion Antibody Exchange, Inc., to exchange transfusion antibody data between hospital systems."

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Clinician researcher Sean Stowell (Emory University) describes how patient movement between healthcare facilities leads to delayed hemolytic transfusion reactions (DHTRs), hyperhemolysis, and patient death.

The video lecture describes this from 41:00 to 43:00.

Listen here »

Letter to Wellsky from Samaritan Hospital

"We believe in the importance of being able to exchange red blood cell alloantibody information between hospitals."

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Letter to Haemonetics, Soft, Sunquest, & Wellsky from University of California Health - UC Davis, UC San Diego, UC Irvine, UC Los Angeles (UCLA), UC San Francisco (UCSF)

"As innovators in healthcare, we at the University of California (UC) Health pride ourselves in adopting available technologies to keep up with, and set, trends; the exchange of red blood cell (RBC) alloantibody information between hospitals is one such innovation."

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Letter to Wellsky from University of Florida - Jacksonville

"I believe that access to antibody data from hospitals outside of our system will improve transfusion safety through shared knowledge of evanescent antibodies which are otherwise undetectable and may cause delayed hemolytic transfusion reactions."

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Letter to Cerner from University of Alabama - Birmingham

"There is an urgent and unmet neet to exchange transfusion and antibody data between hospital systems in our country."

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Letter to Haemonetics, SCC Soft Computer, Sunquest, and Wellsky from University of Pittsburgh

"The southwestern Pennsylvania region has had a centralized database of patient red cell antibody status for the last 25 years. As Medical Director of the regional transfusion service covering 22 hospitals, I can attest to the added safety. In fact, we have published a manuscript showing that acute hemolytic transfusion reactions from ABO errors have been prevented using this database."

Read more »

Jeanne Hendrickson discusses the Alloantibody Exchange at the Margot S. Kruskall Lectureship

"Delayed Hemolytic Transfusion Reactions: Diagnosis, Treatment, and Future Directions"

Lecture Schedule »

Letter to Cerner from MedStar Health

"We are writing this letter as your client to urge you to consider updating your software to allow participation in the Alloantibody Exchange. We consider this functionality to be of the utmost importance and anticipate it will be a major differentiation in our future choice of BBIS."

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Letter to Haemonetics from Duke Health

"As a practicing transfusion medicine specialist at a major academic medical center for the past 25 years, I understand well our collective need to be able to exchange red blood cell alloantibody information between hospitals."

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Letter to Sunquest from University of Virginia

"We use the Sunquest blood bank information system at UVA. As medical director of the UVA blood bank, I am writing this letter to express our strong interest in having you participate in the proposed US-wide red blood cell antibody exchange, the Alloantibody Exchange, as a patient safety initiative."

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Letter to Haemonetics from Weill Cornell

"I strongly urge you to consider updating your software such that participation in such an antibody exchange is possible."

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Letter to Sunquest from Cedars Sinai

"Over the years it has become clear that the capability to share red blood cell alloantibody information amongst hospital transfusion services has important patient safety benefits."

Read more »

Letter to Wellsky from University of Vermont

"We believe in the importance of being able to exchange red blood cell antibody information between hospitals."

Read more »

Letter to Haemonetics from Grady Memorial Hospital

"At Grady, we strive to provide the best care possible for our patients. ... This is why we are requesting your participating in a red blood cell alloantibody registry, developed by Transfusion Antibody Exchange, Inc, to exchange transfusion antibody data between hospital systems."

Read more »

Letter to Haemonetics, SCC Soft Computer, Sunquest, and Wellsky from Stanford University

"At Stanford Medicine, we are strongly committed to innovation and continued improvement in patient safety. We believe that the safety of transfusion medicine will improve from the exchange of red blood cell alloantibody information between hospitals across the nation."

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Letter to Haemonetics from Cleveland Clinic

"As your client, we are writing this letter to express our interest in having Haemonetics participate in the proposed US-wide red blood cell antibody exchange, the Alloantibody Exchange, as a patient safety initiative. We urge you to consider updating your software such that participation in such an antibody exchange is possible."

Read more »

Letter to Haemonetics from Seattle Children's Hospital

"We serve as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho and receive patients from across the country as they seek out routine care as well as innovative treatments such as stem cell transplant, immunotherapy, and gene therapy. Exchange of red blood cell alloantibody information between hospitals is an important advancement and innovation in transfusion medicine safety."

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Letter to Soft Computer from Rush University Medical Center

"Your willingness to participate in the Alloantibody Exchange to enable the exchange red blood cell alloantibody information between hospitals is appreciated and truly improves patient care."

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Letter to Cerner from Boston Children's Hospital

"As a representative of Boston Children’s Hospital, the #1 U.S. News & World Report Children’s Hospital for 9 years in a row, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."

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Letter to Haemonetics & Soft Computer from Mayo Clinic

"As transfusion medicine physicians delivering care within such a healthcare environment, we daily experience the very real need of being able to share RBC alloantibody information between your two different transfusion laboratory information systems within our own healthcare organization as well as between transfusion laboratory information systems with other healthcare organizations across our nation."

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Letter to all vendors from Harvard Hospitals

"As leaders in healthcare, we as members of the Massachusetts General Brigham (Massachusetts General Hospital, Brigham and Women’s Hospital and affiliated hospitals) system seek to adopt new technology to improve the safety and operational efficiency of our blood banks. The exchange of red blood cell (RBC) alloantibody information between hospitals through vendor collaboration, as proposed by the Alloantibody Exchange, is one such innovation."

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Letter to Haemonetics from Cincinnati Children's Hospital

"As a representative of Cincinnati Children’s Hospital, a top children's hospital according to U.S. News & World Report, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."

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Letter to all vendors from University of Minnesota

"As a blood bank information system client, we are writing this letter to express our interest in having you participate in the proposed US-wide red blood cell antibody exchange as a patient safety initiative."

Read more »

Letter to all vendors from Tufts Medical Center

"This novel project will improve transfusion safety by sharing the incidence of possibly undetectable evanescent antibodies."

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Letter to all vendors from University of Maryland

"Patients who are chronically transfused and allo-immunized will benefit from receiving phenotypically matched blood but may not receive that standard of care depending on the hospital they receive transfusion at; as a result they may become further alloimmunized unnecessarily."

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Letter to WellSky from Washington University in St. Louis

"As medical directors for your client, we are writing this letter to express our interest in having your participate in the proposed US-wide red blood cell antibody exchange."

Read more »

Letter to all vendors from Atrium Health-Wake Forest

"As a representative of Atrium Health Wake Forest Baptist, I proudly and enthusiastically support the exchange of alloantibody and antigen data to improve transfusion safety."

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Alloantibody Exchange wins HHS Secretary's "Challenge on Equity."

The Office of the Assistant Secretary for Health (OASH), within the U.S. Department of Health and Human Services (HHS), submission for a red blood cell antibody repository has been chosen for development as part of the HHS Secretary’s “Challenge on Equity.” The project is expected to be implemented in the next two years and is one of 24 innovative projects selected to advance equity in programs, policies, and processes across the agency. (page 5)

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ABOUT US

  We're a 501c3 nonprofit organization with a mission to make blood transfusion safer by enabling blood banks to share a patient's alloantibody history via their blood bank software vendor. Contact us at
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Ronald 'George' Hauser, MD

President, Founder.
Yale University School of Medicine.

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Jeanne Hendrickson, MD

Board member, Founder.
Emory University School of Medicine.

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Khalda A. Ibrahim, MD

Board member.
University of California, Los Angeles.

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Neisha Lovett

Director of Communications.
University of New Haven.

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Greg Olsen, MD, MBA

Board member.
University of Florida.

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Christopher Tormey, MD

Board member, Founder.
Yale University School of Medicine.

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Ugo Ugwuowo, MD

Director of Special Projects.
Yale University School of Medicine.

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Andrew Loza, MD, PhD

Director of Software.
Yale University School of Medicine.